In multiple randomized and randomized controlled studies HBOT at 1.5 ATA oxygen demonstrated statistically significant symptomatic and cognitive or cognitive improvements alone in patients with mild traumatic brain injury Persistent Post-concussion Syndrome. Positive and negative results occurred at lower and higher doses of oxygen and pressure. Increased pressure within a narrow range appears to be the more important effect than increased oxygen which is effective over a broad range. Improvements were greater when patients had comorbid Post Traumatic Stress Disorder. Despite small sample sizes, the 1.5 ATA HBOT studies meet the Centre for Evidence-Based Medicine Level 1 criteria and an American Society of Plastic Surgeons Class A Recommendation for HBOT treatment of mild traumatic brain injury persistent postconcussion syndrome.
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Introduction. This is a scientific review of the evidence for hyperbaric oxygen therapy treatment of non-penetrating mild traumatic brain injury (mTBI) Persistent PostConcussion Syndrome (PPCS) ().The conclusions and recommendations are based on the Centre for Evidence-Based Medicine (CEBM) Levels of Evidence and the American Society of Plastic Surgeons Grade Practice Recommendation guidelines …
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